tianeptine sodium Powder

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tianeptine sodium powder

Tianeptine sodium powder salt, also known as Stablon or Coaxil, usually appears as a white or slightly yellow crystalline powder. It is similar in appearance to other powdery solids, although tiny grains or depressions may appear on the surface. The solubility in water is low. It is soluble in some organic solvents such as ethanol, ether and chloroform. However, its solubility in silver nitrate, mercury nitrate and cerium chloride is high. Considered a surfactant, it reduces the surface tension of liquids. Reducing surface tension, the cohesive force between the surface layer of a liquid and the molecules inside, makes it easier for the liquid to spread and transfer. is a drug with antidepressant and anxiolytic properties and its chemical name is 7-hydroxy-5,6,7,8-tetrahydronaphtho[1,2-a]pyridin-9-one. This article will focus on the physical properties of Tianeptine.

Buy Tianeptine sodium powder (Coaxil)

Tianeptine sodium powder (Coaxil) is an antidepressant in the form of sodium salt, used in the treatment of depression, alcoholism and drug addiction, is an agonist of μ-opioid receptors.
Tianeptine action: increases the reverse neuronal uptake of serotonin by neurons of the cerebral cortex, increases the activity of the hippocampal pyramidal cells and accelerates their recovery, after functional inhibition. Tianeptine improves mood, improves tone, euphoria. At high dosages, side effects are possible in the form of nausea, respiratory depression, even heart failure. tianeptine sodium Powder

Synonyms	Tianeptine Coaxil S-1574 JNJ-39823277 TPI-1062 Stablon 30123-17-2 Tatinol
IUPAC	7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino] heptanoic acid sodium salt
Formula	C21H25ClN2O4S
Molecular weight	436.953 g/mol
CAS	66981-73-5
Appearance	Powder
Purity	≥ 98%

Tianeptine and other chemicals sold on this website are designed and must be used strictly for research and forensic medical examination.

Storage conditions of this chemical: in a cool and dry place. The stability of this chemical compound can last up to 2 years, under the right storage conditions. tianeptine sodium Powder

Elemental Analysis

C, 54.96; H, 5.27; Cl, 7.72; N, 6.10; O, 13.94; S, Na, 5.01 tianeptine sodium Powder

The invention relates to a synthesis process of the drug Tianeptine sodium salt, in particular to a method for synthesizing thieneptine sodium by using 3-chloro-6-methyldibenzo [c, f] [1,2] thiazazol-11 (6H) – keto-5,5 – dioxide as the starting material, forming a Schiff base with amine, reducing, hydrolyzing and finally freeze-drying to salt. The starting material of the method is stable, easy to purchase, and the process is simple. The overall reaction conditions of the synthesis route are mild, the experimental operation is simple, and it is easy to realize industrial production.

In non stressed rats, the treatment of Tianeptine can prevent the increase of the mRNA level of corticotropin releasing factor (CRF) in dBNST induced by CMS, and reduce the mRNA level of corticotropin releasing factor (CRF) in dBNST. In the pressure avoidance control group and CMS exposed rats, Tianeptine treatment significantly reduced the level of CRF mRNA of ventral BNST and CEA. In the basolateral nucleus (BLA) of the amygdala in anesthetized rats, Tianeptine blocked the stress induced enhancement of PB in the CA1 region, but did not affect the stress induced enhancement of LTP. In the amygdala, hippocampus and LTP of anesthetized rats, Tianeptine was enhanced by administration of enhanced PB under non stress conditions. tianeptine sodium Powder

In rats, Tianeptine attenuates peripheral induction rather than central, LPS or IL-1 β Behavioral signs of induced morbid behavior. In rats, Tianeptine caused the normalized proportion of AMPA/kainate receptor mediated current amplitude ratio from NMDA receptor and prevented the attenuation of stress induced inactivation of NMDA-EPSCS. In both control and stressed animals, in the temporal cortex and dentate gyrus of the rat, Tianeptine significantly reduced cell apoptosis, but had no effect on Amons in the Horn of Africa. In the nucleus accumbens only, Tianeptine (2.5 mg/kg, intraperitoneal injection) increases extracellular dopamine. In the two nucleus accumbens and striatum, Tianeptine significantly increased the extracellular concentrations of hydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). tianeptine sodium Powder

The following is a common laboratory synthesis method for Tianeptine sodium salt:

Preparation of raw materials:

O-Nitrochlorobenzene

O-nitrochlorobenzene is a common organic synthesis raw material that can be obtained through purchase or chemical synthesis methods. The structural formula of o-nitrochlorobenzene is C6H4ClNO2, with a molecular weight of 153.5.

Triethylamine

Triethylamine is an organic base with strong hygroscopicity. It can be prepared through the reaction of ethyl acetate and ammonia, or it can be purchased directly. The structural formula of triethylamine is (CH3CH2) 3N, with a molecular weight of 101.1.

Sodium acetate

Sodium acetate is an organic salt that is easily soluble in water and can be prepared by reacting acetic acid with sodium hydroxide, or directly purchased. The structural formula of sodium acetate is CH3COONa, with a molecular weight of 134.9.

Water

Water is the most common solvent in the laboratory and can be used to dissolve raw materials and products.

Synthesis steps:

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Mix o-nitrochlorobenzene, triethylamine, and water together, heat to reflux state, and the reaction time is about 30 minutes to 1 hour.

After the reaction is completed, add sodium acetate and water, and then heat until dissolved.

Cool the solution to precipitate crystals. Stir with a glass rod and filter the crystals.

Wash the crystal to remove any residual mother liquor. Then dry the crystal to obtain the crude Tianeptine product.

Add the crude Tianeptine to an appropriate amount of water and heat it to a dissolved state. Add an appropriate amount of sodium hydroxide solution to adjust the pH value to around 7, then add an appropriate amount of activated carbon, heat and boil for a few minutes.

Filter and remove activated carbon particles, cool the solution, and precipitate crystals. Stir with a glass rod and filter the crystals to obtain Tianeptine high-quality products. tianeptine sodium Powder